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Home - Daily Science - Enhanced FnCas9: A Breakthrough in Precision Genome Editing
Enhanced FnCas9: A Breakthrough in Precision Genome Editing
Indian scientists have developed a groundbreaking enhancement to the CRISPR-Cas9 gene-editing system, offering new hope for treating genetic disorders and advancing medical research.

Enhanced FnCas9: A Breakthrough in Precision Genome Editing

Daily Science 01/08/2024Basanta Kumar SahooBy Basanta Kumar Sahoo2 Mins Read

A New Era of CRISPR Precision

Scientists in India have engineered a groundbreaking enhancement to the CRISPR-Cas9 gene-editing system, achieving unprecedented precision and efficiency. This innovation, led by researchers at the CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB) in New Delhi, has the potential to revolutionize gene therapy and diagnostics, offering hope for treating genetic disorders and advancing medical research.

Enhancing FnCas9 for Superior Performance

The enhanced system, known as enhanced FnCas9 (enFnCas9), addresses the limitations of traditional CRISPR-Cas9, which can sometimes cause unintended “off-target” effects. By modifying the amino acids in FnCas9, the enzyme responsible for cutting DNA, researchers have significantly improved its binding affinity and flexibility, enabling it to target and edit specific DNA sequences with greater accuracy and efficiency.

Applications in Diagnostics and Therapeutics

The potential applications of enFnCas9 are vast. In diagnostics, the enzyme’s enhanced ability to identify single-nucleotide changes in DNA could lead to more sensitive and accurate tests for a wider range of genetic disorders. In therapeutics, enFnCas9 holds promise for correcting disease-causing mutations with minimal risk of off-target effects, as demonstrated in a study on Leber congenital amaurosis type 2 (LCA2), a form of inherited blindness.

A Step Towards Affordable Gene Therapies

One of the most exciting aspects of this breakthrough is its potential to make gene therapies more accessible and affordable for people in low- and middle-income countries. By developing indigenous intellectual property for this high-precision gene editor, Indian researchers have paved the way for the development of cost-effective treatments for a variety of genetic disorders.

Summary: Researchers at CSIR-IGIB have engineered an enhanced version of the CRISPR-Cas9 gene-editing system, called enFnCas9, which demonstrates superior precision and efficiency compared to traditional methods. This breakthrough holds promise for improving diagnostics and developing safer and more affordable gene therapies for a wide range of genetic disorders, particularly in low- and middle-income countries.

Key Learnings:

PointDescription
Enhanced Precision:enFnCas9 exhibits higher precision in targeting and editing specific DNA sequences, minimizing off-target effects.
Increased Efficiency:The enhanced enzyme demonstrates greater efficiency in cutting target DNA, improving the overall gene-editing process.
Applications:enFnCas9 has potential applications in diagnostics, gene therapy, and medical research, particularly for genetic disorders.
Affordability:This breakthrough could lead to the development of more affordable gene therapies for people in low- and middle-income countries.
Indian Innovation:The development of enFnCas9 is a testament to the growing scientific and technological capabilities of India.
Basanta Kumar Sahoo
Basanta Kumar Sahoo

Basant Kumar Sahoo is a seasoned writer with extensive experience in crafting tech-related articles, insightful editorials, and engaging sports content. With a deep understanding of technology trends, a knack for thought-provoking commentary, and a passion for sports, Basant brings a unique blend of expertise and creativity to his writing. His work is known for its clarity, depth, and ability to connect with readers across diverse topics.

CRISPR FnCas9 gene editing Gene Therapy genetic disorders India precision medicine
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